Which symptoms are commonly associated with a hemolytic transfusion reaction?

• A. Nausea and constipation
• B. Rash and watery eyes
• C. Hyperglycemia and polyuria
• D. Headache and tachycardia

Answer: (D)

Hemolytic transfusion reactions occur when recipient antibodies attack donor red blood cells, triggering a systemic inflammatory response and cardiovascular changes. This often includes tachycardia as the heart rate rises to maintain perfusion during the reaction, and headaches can accompany the fever and inflammatory process. Among the options, headache with tachycardia best reflects the generalized systemic involvement seen in an acute hemolytic reaction. The other pairings point to reactions or symptoms not typical for this type, such as allergic-type signs (rash and watery eyes) or metabolic symptoms (hyperglycemia and polyuria).