In COPD patients, what SpO2 range is generally targeted to avoid CO2 retention?

• A. SpO2 around 88–92%, titrated to maintain that range.
• B. SpO2 around 95–100%.
• C. SpO2 around 70–80%.
• D. SpO2 around 92–96% with no titration.

Answer: (A)

In COPD, oxygen therapy must be carefully balanced because many patients with chronic CO2 retention rely on a lower-than-normal drive to breathe. Giving too much oxygen can blunt that respiratory drive and worsen CO2 retention, leading to respiratory acidosis and other complications. The goal is to keep oxygenation sufficient but not excessive, which is why the target SpO2 is about 88–92% and oxygen is titrated to stay within that range. This approach provides enough oxygen for tissues while reducing the risk of CO2 buildup; clinicians monitor SpO2 continuously and adjust the oxygen flow to maintain that window, checkingABGs if needed to verify gas status. If SpO2 trends above 92%, the oxygen should be reduced; if it drops below 88%, oxygen should be increased cautiously.