Febrile non-hemolytic transfusion reaction is typically characterized by which symptom?

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Multiple Choice

Febrile non-hemolytic transfusion reaction is typically characterized by which symptom?

Explanation:
Fever during or shortly after a transfusion is the hallmark of a febrile non-hemolytic transfusion reaction. This occurs because cytokines released by donor leukocytes (or antibodies in the recipient reacting to donor leukocytes) trigger a fever response. Because of that mechanism, fever is the defining symptom. Rash and itching point more toward an allergic transfusion reaction, which involves hypersensitivity to plasma proteins. Severe hypotension suggests a more dangerous reaction such as anaphylaxis or septic transfusion reaction. Bleeding at the injection site isn’t a feature of FNHTR.

Fever during or shortly after a transfusion is the hallmark of a febrile non-hemolytic transfusion reaction. This occurs because cytokines released by donor leukocytes (or antibodies in the recipient reacting to donor leukocytes) trigger a fever response. Because of that mechanism, fever is the defining symptom.

Rash and itching point more toward an allergic transfusion reaction, which involves hypersensitivity to plasma proteins. Severe hypotension suggests a more dangerous reaction such as anaphylaxis or septic transfusion reaction. Bleeding at the injection site isn’t a feature of FNHTR.

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